Anahid Amiri

Anahid Amiri M.Sc.

+49 6151 16-21928

Alarich-Weiss-Straße 16
64287 Darmstadt

Office: L2|07 203

Master project

Structural analysis of cells by AFM nanospectroscopy

Description of project

The transition of healthy epithelial cells to carcinoma is associated with an alteration in structure and organization of the cytoskeleton of the cells. A comparison of the mechanical properties of cancerous and healthy cells indicated a larger deformability of the cancer cells based on averaging the mechanical properties on single cells. However, the exact reason for softening of the cancerous cells compared to their counterparts and the molecular mechanisms underlying this alteration remains unclear. On this project we focus on nanomechanical spectroscopy of healthy and cancerous epithelial cells by means of atomic force microscopy with high lateral and depth precision.
For more information please refer to Christian Dietz.

Conference talks

1 Anahid Amiri and Christian Dietz
Structural analysis of healthy and cancerous ductal epithelial breast type celly by nanomechanical spectroscopy
Advances in single-molecule research for biology and nanoscience-21st annual Linz winter workshop, Feb. 2019, Linz, Austria

Publications

3 Appel, Christian ; Kuttich, Björn ; Stühn, Lukas ; Stark, Robert W. ; Bernd Stühn
Structural Properties and Magnetic Ordering in 2D Polymer Nanocomposites: Existence of Long Magnetic Dipolar Chains in ZeroField
[Online-Edition: https://doi.org/10.1021/acs.langmuir.9b02094]
In: Langmuir, ISSN 0743-7463, (2019)
2 Stühn, Lukas ; Fritschen, Anna ; Choy, Joseph ; Dehnert, Martin ; Dietz, Christian:
Nanomechanical sub-surface mapping of living biological cells by force microscopy.
[Online-Edition: https://doi.org/10.1039/C9NR03497H]
In: Nanoscale, ISSN 2040-3364, (2019)
1 Grefe, Ann-Kathrin; Kuttich, Björn; Stühn, Lukas; Stark, Robert; Stühn, Bernd:
Oriented crystallization of PEG induced by confinement in cylindrical nanopores: Structural and thermal properties.
[Online-Edition: https://doi.org/10.1039/C9SM00053D]
In: Soft Matter ISSN 1744-683X, (2019)

go to list