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Dr. rer. nat. Asma Siddique

Contact

work +49 6151 16-21928
fax +49 6151 16-21921

Work L2|07 203
Peter-Grünberg-Straße 16
64287 Darmstadt

  • Biomicrofluidics
  • Biocompatible polymers
  • Surface functionalisation
  • Cell-surface interfaces
  • Mimicking vascular microenvironment at high shear stress
  • Mammalian, fungal, yeast, bacterial cell culture
Surface modification of PDMS based microfluidic devices for improved cell adhesion under high shear stress
9 MF Kilb, VI Engemann, A Siddique, RW Stark, K Schmitz (2021):
Immobilisation of CXCL8 gradients in microfluidic devices for migration experiments
Colloids and Surfaces B: Biointerfaces 2021 198, 111498.
DIO: https://doi.org/10.1016/j.colsurfb.2020.111498
[Articlel]
8 A Siddique, I Pause, S Narayan, L Kruse, RW Stark (2021):
Endothelialization of PDMS-based microfluidic devices under high shear stress conditions
Colloids and Surfaces B: Biointerfaces 2021 197, 111394
DOI: https://doi.org/10.1016/j.colsurfb.2020.111394
[Articlel]
7 MF Kilb, V Engemann, A Siddique, RWvStark, K Schmitz (2021)
Immobilisation of CXCL8 gradients in microfluidic devices formigration experiments
DOI: https://doi.org/10.1016/j.colsurfb.2020.111498
[Articlel]
6 Siddique, Asma ; Meckel, Tobias ; Stark, Robert W. ; Narayan, Suman :
Improved cell adhesion under shear stress in PDMS microfluidic devices.
[Online-Edition: http://dx.doi.org/10.1016/j.colsurfb.2016.11.011]
In: Colloids and Surfaces B-Biointerfaces, 150 S. 456-464. ISSN 0927-7765
[article] , (2017)
5 Siddique, Asma ; Gul, Ambreen ; Irfan, Muhammad ; Nadeem, Muhammad ; Syed, Quratulain
Comparison of different pretreatment methods for efficientconversion of bagasse into ethanol
[Online-Edition: DOI: 10.1080/17597269.2016.1215066]
In: Biofuels, 8:1, 135-141
[Artikel], (2017)
4 Siddique, Asma ; Bashir, Aftab ; Latif, Farooq
Exploration of unique relationamong industrial fungi by statistical analysis
In: Songklanakarin J. Sci. Technol. 34(6), 607-613
[Artikel], (2012)
3 Khan, S.A. ; Siddique, A. ; Latif, F.
Fibrolytic enzyme production fromHumicola insolens and its applications in animal feed
In: Pakistan J. Zool. Suppl.Ser. 9:41-45
[Artikel], (2009)
2 Anwar, Farooq ; Siddique, Asma ; Iqbal, Shahid ; Asi, M. Rafique
Stabilization of sunflower oil with Moringa oleifera leaves under ambient storage
In: Journal of Food Lipids, 14: 35-49
[Artikel], (2007)
1 Siddique, A. ; Anwar, F. ; Manzoor, M. ; Fatima, A
Antioxidant activity ofdifferent solvent extracts of Moringa oleifera leaves under accelerated storage of Sunflower oil
In: Asian Journal of Plant Science, 4(6): 630-635
[Artikel], (2005)
2 Asma Siddique, Isabelle Pause, Suman Narayan and Robert W. Stark
Stability of protein coatings inside microfluidic devices under flow conditions
µFlu’18-NEGF’18, Feb. 2018, Strasbourg, France
1 Asma Siddique and Robert W. Stark
Microfluidics; A competent analytical tool in life science
Emerging trends in life sciences for sustainable development, Oct. 2014, Lahore Pakistan
3 Asma Siddique, Isabelle Pause, Suman Narayan and Robert W. Stark
Stability of protein coatings inside microfluidic devices under flow conditions
µFlu’18-NEGF’18, Feb. 2018, Strasbourg, France
2 Asma Siddique, Suman Narayan and Robert W. Stark
Stable protein coating inside PDMS microfluidic devices for improved cell adhesion under shear stress
Lab-on-Chip & Microfluidics 2017, May 2017, Munich, Germany
1 Asma Siddique, Suman Narayan and Robert W. Stark
Stable protein coating inside PDMS microchannels for cell growth under flow conditions
EMBL Conference, Microfluidics 2012, Jul. 2014, EMBL Germany
  • “Fortgeschrittenenpraktikum II” (materials science department)
  • Mentoring of bachelor- and master-students
Many of the vascular functions, hemodynamic forces, cellular interactions and related diseases are strictly related to of physical geometry of vasculature. Combination of microfluidics and cell biology offers a physiologically realistic platform to reproduce various vascular models in laboratory leading to better understandings about cell and tissue physiology in 3D environment. Under a shear flow, however, the stability of cells that were grown on physically adsorbed proteins is short lived, which limits long-term cell studies. Focusing on this issue various protein-substrate linkages were developed for stable cell growth under high flow conditions (at physiological shear stress in human vasculature). APTES (3-Aminopropyl)triethoxysilane is primarily used to immobilized collagen on PDMS surface for stable endothelial cells growth at long term, high shear stress.